Massive hepatic apoptosis associated with TGF-β1 activation after Fas ligand treatment of IGF binding protein-1–deficient mice
J. Clin. Invest. Julia I. Leu, et al. 111:129 doi:10.1172/JCI16712 [
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Figure 1Increased acute Fas-mediated injury of
IGFBP-1–/– livers following 0.15 μg/g body weight of the Fas agonist was prevented by treatment with IGFBP-1. Hematoxylin and eosin staining of (
a)
IGFBP-1+/+ liver at time 0, (
b)
IGFBP-1–/– liver at time 0 and at (
c) 3 hours, (
d) 3 hours (higher magnification), (
e) 5 hours, (
f) 7 hours after Fas challenge, (
g) 7 hours after IGFBP-1 treatment and Fas challenge, and (
h)
IGFBP-1+/+ liver at 7 hours after Fas challenge. Scale bars: 50 μm except in
d, which is 10 μm. BP-1, IGFBP-1.
