The antitumor effects of IFN-α are abrogated in a STAT1-deficient mouse
J. Clin. Invest. Gregory B. Lesinski, et al. 112:170 doi:10.1172/JCI16603 [
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Figure 8Effects of IFN-α on the survival of C57BL/6 and STAT1-deficient mice bearing locoregional B16F10 metastases. IFN-α treatment (open triangles) significantly prolonged the survival of (
a) C57BL/6 mice (
P = 0.002) but not (
b) STAT1-deficient mice (
P = 0.73) bearing B16F10 locoregional metastases as compared with PBS-treated (filled circles) controls. There were 10 mice in each group.
