The antitumor effects of IFN-α are abrogated in a STAT1-deficient mouse
J. Clin. Invest. Gregory B. Lesinski, et al. 112:170 doi:10.1172/JCI16603 [Go to this article.]

Figure 7
Histochemical analysis. B16F1 tumors from C57BL/6 mice treated with (a) PBS or (b) IFN-α and STAT1-deficient mice treated with (c) PBS or (d) IFN-α were stained with hematoxylin and eosin and analyzed at ×40. A striking degree of tumor cell necrosis was observed in STAT1-deficient mice treated with either PBS or IFN-α. A similar degree of necrosis was observed in PBS-treated C57BL/6 mice. Notably, the least degree of tumor cell necrosis was observed in C57BL/6 mice treated with IFN-α, which was the only group exhibiting prolonged survival.