The antitumor effects of IFN-α are abrogated in a STAT1-deficient mouse
J. Clin. Invest. Gregory B. Lesinski, et al. 112:170 doi:10.1172/JCI16603 [Go to this article.]

Figure 5
The antitumor effects of IFN-α are not enhanced after reconstitution of STAT1 signaling within the melanoma cell. (a) IFN-α treatment (open triangles) significantly (P < 0.01) prolonged the survival of C57BL/6 mice (n = 6 mice per group) bearing AGS-1 cells infected with empty vector (AGS-1^MSCV) as compared with PBS-treated mice (filled circles). (b) IFN-α treatment (open triangles) also significantly (P < 0.01) prolonged the survival of C57BL/6 mice (n = 6 mice per group) challenged with the STAT1-reconstituted AGS-1 melanoma cell line (AGS-1^STAT1) as compared with PBS-treated mice (filled circles). These results are representative of two separate determinations.