Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice
J. Clin. Invest. Karine Thébault-Baumont, et al. 111:851 doi:10.1172/JCI16584 [Go to this article.]

Figure 6
T cell response of wild-type (a) and Ins2^–/– (b) NOD mice to proinsulin 2 peptides. Each individual mouse was immunized against one single peptide of the proinsulin 2 peptide library described in Table 1, in CFA. Spleen cells were tested against the peptide used for immunization, and ovalbumin peptide 323-339 as control. IL-2 was evaluated in supernatants as described in Methods. Each histogram represents the mean ± SD of triplicate wells, expressed in cpm.