Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice
J. Clin. Invest. Karine Thébault-Baumont, et al. 111:851 doi:10.1172/JCI16584 [
Go to this article.]
Figure 2Incidence of diabetes in BC4 intercross progeny. The number of Ins2
+/+ (filled diamonds), Ins2
+/– (open squares), and Ins2
–/– (filled circles) mice was respectively 9, 14, and 5 among female mice (
a) and 7, 14, and 3 among male mice (
b). Significant differences were seen between Ins2
+/+ and Ins2
–/– mice (
P < 0.001 and
P < 0.05, respectively, in female and male mice) and between Ins2
–/– and Ins2
+/– mice (
P < 0.001 and
P < 0.01, respectively, in female and male mice), but not between Ins2
+/– and Ins2
+/+ mice.
