PPAR-γ receptor ligands: novel therapy for pituitary adenomas
J. Clin. Invest. Anthony P. Heaney, et al. 111:1381 doi:10.1172/JCI16575 [
Go to this article.]
Figure 4Mechanism of PPAR-γ–mediated apoptosis. Western blot analysis of rosiglitazone-treated human nonfunctioning and murine αT3 gonadotroph tumor cells demonstrated increased expression of the proapoptotic protein BAX (
a and
b) and decreased anti-apoptotic Bcl-2 (
c). Dose-dependent increase in TZD-mediated cleaved caspase-3 and a concordant decrease in uncleaved caspase-3 supports the proapoptotic effect of PPAR-γ ligands in pituitary tumors (
d). Jurkat B cell leukemia cells served as a positive control. αT3, murine αT3 gonadotroph tumor cells. *
P < 0.01, **
P < 0.03, ***
P < 0.02.
