PPAR-γ receptor ligands: novel therapy for pituitary adenomas
J. Clin. Invest. Anthony P. Heaney, et al. 111:1381 doi:10.1172/JCI16575 [
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Figure 1PPAR-γ is abundantly expressed in human pituitary tumors. Western blot (
a) and immunocytochemical (
b and
c) analysis depicting abundant PPAR-γ expression in surgically resected pituitary tumors, in comparison to PPAR-γ expression in two normal pituitary tissue extracts (NP). β-actin immunoblotting confirmed equivalent total protein loading. MCF-7 breast cancer cells served as a positive control. M, protein marker; NF, nonfunctioning; GH, GH-secreting; PRL, PRL-secreting. Arrow indicates PPAR-γ immunopositive cells.