The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity
J. Clin. Invest. Benoit Viollet, et al. 111:91 doi:10.1172/JCI16567 [
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Figure 5Increased daily urinary catecholamine excretion in
AMPKα2–/– mice. Daily urinary (
a) epinephrine, (
b) norepinephrine, and (
c) dopamine excretion in
AMPKα2–/– mice. All results are expressed as mean ± SEM (
n = 6). *
P < 0.05, **
P < 0.01 vs. control group by unpaired, two-tailed
t test. Also shown are effect of phentolamine and propranolol, α- and β-adrenergic blockers, respectively, on the response of glucose challenge of control (
d) and
AMPKα2–/– (
e) mice. All results are expressed as mean ± SEM (
n = 5). *
P < 0.05, **
P < 0.01, saline- vs. phentolamine-treated group by unpaired, two-tailed Student
t test;
P not significant for saline- vs. propranolol-treated group.
