The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity
J. Clin. Invest. Benoit Viollet, et al. 111:91 doi:10.1172/JCI16567 [
Go to this article.]
Figure 2AMPKα2–/– mice are AICAR-resistant, glucose intolerant, and exhibit impaired glucose-stimulated insulin secretion. (
a) AICAR tolerance test. (
b) OGTT. (
c) Plasma glucose and insulin levels at time 20 minutes during OGTT. All results are expressed as mean ± SEM (
n = 6–10). *
P < 0.05, *
*P < 0.001, ***
P < 0.0001 vs. control group by unpaired, two-tailed Student
t test. NS, not significant.
