Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor
J. Clin. Invest. Li Yang, et al. 111:727 doi:10.1172/JCI16492 [
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Figure 7CTL function is elevated in
EP2–/– mice. Spleen cells from MC26-immunized
EP2–/– (white bars) and wild-type mice (black bars) were cocultured with irradiated MC26 cells for 4 days. The cells were then washed and incubated with different ratios of
51Cr-labeled MC26 cells. After a 6-h incubation, supernatants were harvested and radioactivity was measured using a gamma counter. The maximum and spontaneous release and the percentage of specific
51Cr release were determined. Data shown are representative of two independent experiments with similar results.
