Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor
J. Clin. Invest. Li Yang, et al. 111:727 doi:10.1172/JCI16492 [Go to this article.]

Figure 1
Decreased tumor size and increased host survival in EP2^–/– mice. (a) Tumor growth of MC26 was significantly attenuated in EP2^–/– host mice. A cell suspension containing 5 × 10⁵ MC26 cells in 100 μl PBS was injected subcutaneously into the right flank of EP2^–/– (white bars) and wild-type mice (black bars) in the BALB/c background. Tumor volume was determined by direct measurement of tumor dimensions, using calipers. Results are presented as the mean tumor volume ± SEM (n = 34 for both EP2^–/– and wild-type mice). (b) Survival plot of EP2^–/– and wild-type mice after 3LL tail vein injection. Cell suspensions of 3LL containing 5 ×10⁵ cells in 100 μl PBS were injected into the tail vein of EP2^–/– (dashed line) and wild-type mice (solid line) on the C57BL/6 background (n = 11 for both EP2^–/– and wild-type mice). The time of death, or when mice became moribund, was recorded and plotted as percentage of survival.