Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice
J. Clin. Invest. Zengxuan Nong, et al. 112:367 doi:10.1172/JCI16484 [Go to this article.]

Figure 3
Analyses of aortic atherosclerosis in recipient mice after BMT on either a regular chow (a) or Western diet (b). On the regular chow diet (a), the mean lesion area was significantly increased in apoE-KO × HL-KO mice transplanted with apoE-KO bone marrow (a, left) (apoE-KO → apoE-KO × HL-KO, circles) as compared with the control study group (squares). In contrast, the mean lesion area was significantly reduced in apoE-KO mice transplanted with apoE-KO × HL-KO bone marrow (a, right) (apoE-KO × HL-KO → apoE-KO, circles) as compared with that of the control study group (squares). On the Western diet (b), similar increases in the mean lesion area of apoE-KO × HL-KO mice transplanted with apoE-KO bone marrow (b, left) (apoE-KO → apoE-KO × HL-KO, circles) were evident as compared with the control study group (squares). However, the mean lesion area was similar between apoE-KO mice transplanted with apoE-KO × HL-KO bone marrow (b, right panel) (apoE-KO × HL-KO → apoE-KO, circles) and the control study group (squares).