Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
J. Clin. Invest. Yong-Geun Kwak, et al. 111:1083 doi:10.1172/JCI16440 [
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Figure 4Effect of wortmannin, LY-294002, or AdPTEN on p-Akt and Akt protein expression in lung tissues of OVA-sensitized and -challenged mice. p-Akt and Akt protein expression were measured 72 hours after the last challenge in saline-inhaled mice administered saline intratracheal ly (SAL + SAL), OVA-inhaled mice administered saline (OVA + SAL), OVA-inhaled mice administered drug vehicle (OVA + VEH), OVA-inhaled mice administered wortmannin (OVA + WTM), OVA-inhaled mice administered LY-294002 (OVA + LY), OVA-inhaled mice administered AdPTEN (OVA + AdPTEN), and OVA-inhaled mice administered AdLacZ (OVA + AdLacZ). Results were similar in six independent experiments.
