Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
J. Clin. Invest. Yong-Geun Kwak, et al. 111:1083 doi:10.1172/JCI16440 [
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Figure 13Effect of wortmannin, LY-294002, or AdPTEN on airway responsiveness in OVA-sensitized and -challenged mice. Airway responsiveness was measured 72 hours after the last challenge in mice treated as described in Figure
4 legend. Airway responsiveness to aerosolized methacholine was measured in unrestrained, conscious mice. Mice were placed in the main chamber of a barometric plethysmograph and nebulized first with saline and then with increasing doses (from 2.5 to 50 mg/ml) of methacholine for 3 minutes for each nebulization. Readings of breathing parameters were taken for 3 minutes after each nebulization, during which time Penh values were determined. Data represent mean ± SD from six independent experiments. *
P < 0.05 vs. SAL + SAL;
#P < 0.05 vs. OVA + SAL and OVA + AdLacZ.
