Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood
J. Clin. Invest. Jacqueline D. Trudeau, et al. 111:217 doi:10.1172/JCI16409 [
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Figure 2NRP-V7–reactive T cells detected in peripheral blood indicate their presence in pancreatic islets. The mean (± SEM) percentage of NRP-V7 tetramer-positive CD8
+ B220
– cells within peripheral blood, pancreatic islets, spleen, and pancreatic draining lymph nodes are shown for individual NOD mice of 9–10 (gray bars;
n = 7), 11–14 (black bars;
n = 13), and 15–17 (white bars;
n = 10) weeks of age. The inset shows a representative staining of each tissue from a single 12-week-old mouse. Numbers indicate the percentage of CD8
+ B220
– tetramer-positive cells.
