α1-adrenergic receptors activate Ca²⁺-permeable cationic channels in prostate cancer epithelial cells
J. Clin. Invest. Stephanie Thebault, et al. 111:1691 doi:10.1172/JCI16293 [Go to this article.]

Figure 7
Phe-activated channels are similar to those activated by OAG. Selectivity properties of OAG- and Phe-induced current in LNCaP cells. (a) Cumulative data (mean ± SEM) for OAG (n = 4 cells) and Phe (n = 7 cells) for monovalent (left panel) and divalent (right panel) ion selectivity for Phe- and OAG-induced current. Permeability to Cs⁺ (P_Cs⁺/P_X) and Ca²⁺ (P_Ca²⁺/P_X) was calculated as indicated in Methods. (b) Time course of an inwardly rectifying current in representative LNCaP cells (at V_m –100 mV) in response to 50 μM Phe alone and after coapplication of 100 μM OAG (n = 4). All interventions on each panel are marked by horizontal bars.