α1-adrenergic receptors activate Ca²⁺-permeable cationic channels in prostate cancer epithelial cells
J. Clin. Invest. Stephanie Thebault, et al. 111:1691 doi:10.1172/JCI16293 [Go to this article.]

Figure 5
Phe and OAG activate cationic membrane current in LNCaP cells. (a and b) Superimposed recordings of the baseline current and current in the presence of Phe (50 μM) in representative LNCaP cells (a; pulse protocol is shown above the records) and I-V relationship of Phe-induced current derived from ramp portions of the recordings (b). (c) Phe-induced current (measured at –100 mV). Each trace shows mean ± SEM current density in response to Phe application (horizontal bar) (n = 9). The right-hand panel presents original baseline (top) and Phe-induced (bottom) currents recorded at the times marked by asterisks (pulse protocol is shown above the baseline currents). Superimposed recordings of the baseline current and current in the presence of Phe (50 μM) in representative LNCaP cell exposed to OAG (100 μM) (d) and corresponding I-V relationship (e).