Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny
J. Clin. Invest. Rosalía Lavado-Autric, et al. 111:1073 doi:10.1172/JCI16262 [
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Figure 4Photomicrographs of NeuN-immunostained coronal sections of the primary somatosensory cortex (
a–
d) and hippocampal CA1 (
e and
f) in LID-plus-KI (
a,
c, and
e) and LID-1 (
b,
d, and
f) progeny at P40. In the neocortex of LID-1 pups, borders between layers are more blurred (horizontal dashed lines in
b) than in LID-plus-KI rats (horizontal lines in
a). The number of NeuN-labeled neurons increases both in subcortical white matter and in strata oriens and alveus of hippocampal CA1 of LID-1 rats (
d and
f, respectively) as compared with LID-plus-KI rats (
c and
e). In
g, CNP-positive oligodendrocytes (arrowheads) and BrdU-labeled nuclei (arrows) are shown in layer V of a LID-1 rat from an E14–E16 subgroup. Note that CNP-positive oligodendrocytes are BrdU negative.
