Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny
J. Clin. Invest. Rosalía Lavado-Autric, et al. 111:1073 doi:10.1172/JCI16262 [Go to this article.]

Figure 3
Photomicrographs of cresyl violet–stained coronal sections showing the cytoarchitecture of the PMBSF of the primary somatosensory cortex (a–c) and hippocampal CA1 (d–i) in LID-plus-KI, LID-1, and LID-2 progeny at P40. In the PMBSF of LID-plus-KI pups, borders between layers are clear-cut, as expected in normal animals (horizontal lines in a), whereas in LID-1 and LID-2 pups they are blurred (horizontal dashed lines in b and c). In layer IV of LID-plus-KI pups, barrels are normal and well defined, as indicated by an arrow in a, and demarcated by septae (arrowheads). In contrast, barrels in layer IV of LID-1 and LID-2 pups (b and c) are not seen. Enlargements of the insets outlined in d–f are shown in g–i. In the hippocampus, the differences between LID-plus-KI pups and both LID-1 and LID-2 pups are not prominent at low magnification (compare d with e and f). However, at a higher magnification, the border between strata pyramidale and oriens in CA1 of LID-plus-KI pups is more clear-cut than in LID-1 and LID-2 progeny (compare g with h and i). Note that strata radiatum is thinner in LID-1 and LID-2 pups than in LID-plus-KI pups. The stratum moleculare is also indicated. Magnification for a–c is 54×; 8× for d–f; and 76× for g–i.