Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny
J. Clin. Invest. Rosalía Lavado-Autric, et al. 111:1073 doi:10.1172/JCI16262 [
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Figure 2Histograms showing the percentage of BrdU-labeled cells in various layers of the primary somatosensory cortex and the CA1 and CA3 regions of the hippocampus. Results for the progeny of the E14–E16 subgroups of normal, LID-plus-KI, LID-1, and LID-2 dams are shown in
a,
c, and
e. Results for the E17–E19 subgroups are shown in
b,
d, and
f. Error bars represent SD across layers from the same group. Single asterisk indicates a significant difference between the LID-1 or LID-2 group and their control group (LID-plus-KI and normal groups); crosshatch indicates a significant difference between the LID-1 group and the LID-2 group. The
F and
P values corresponding to layers for which significant differences were found between groups are shown in the upper part of each panel. The degrees of freedom were 3, 9 for the E14–E16 subgroups and 3, 7 for the E17–E19 subgroups. inner plexif., inner plexiform stratum; outer plexif., outer plexiform stratum.
