HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages
J. Clin. Invest. James Dressman, et al. 111:389 doi:10.1172/JCI16261 [
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Figure 8Ritonavir did not induce formation of atherosclerotic lesions in apoE × CD36 null mice. Six-week-old male apoE null and apoE × CD36 double null mice were fed a chow diet and given vehicle (0.01% ethanol) or ritonavir (10 μg/mouse/day) in their drinking water for 6 weeks. At the conclusion of the study the extent of atherosclerotic lesions was quantified as above. Data are presented as mean ± SE.
n = 12. *
P < 0.01 compared with vehicle.
