FTY720 stimulates multidrug transporter– and cysteinyl leukotriene–dependent T cell chemotaxis to lymph nodes
J. Clin. Invest. Shaun M. Honig, et al. 111:627 doi:10.1172/JCI16200 [Go to this article.]

Figure 4
FTY720-mediated migration and S1P-mediated migration are dependent on cysLTs. (a and b) In vitro chemotactic response of T cells from wild-type or 5-LO^–/– mice to CCL19 and FTY720 plus the 5-LO blocker AA-861 or the 12-LO blocker CDC. (c and d) Chemotactic response of T cells from 5-LO^–/– and wild-type mice to CCL19 and S1P plus AA-861 or CDC. (e) Chemotactic response of T cells treated with CCL19 and with FTY720, FTY720 plus AA-861, or FTY720 plus AA-861 plus LTD₄. (f) In vitro chemotactic response of T cells treated with FTY720 or FTY720 supernatant. (g) Chemotactic response of T cells treated with supernatants from FTY720, FTY720 plus AA-861, or FTY720 plus CDC-treated T cells. (h and i) Chemotactic response of fvb wild-type or fvb Abcc1^–/– T cells treated with CCL19 and FTY720 or supernatant from FTY720-treated T cells. (j) In vivo migration from peripheral blood and spleen to LNs in response to FTY720 in 5-LO^–/– mice. Total T cells are indicated.