FTY720 stimulates multidrug transporter– and cysteinyl leukotriene–dependent T cell chemotaxis to lymph nodes
J. Clin. Invest. Shaun M. Honig, et al. 111:627 doi:10.1172/JCI16200 [
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Figure 3FTY720 causes Abcc1- and Abcb1-dependent LN homing in vivo. In vivo migration from peripheral blood and spleen to LNs in response to FTY720 in
fvb wild type (
a),
Abcc1–/– (
b), and
Abcb1–/– (
c). Total T cells are indicated.