Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
J. Clin. Invest. I.R. Garrett, et al. 111:1771 doi:10.1172/JCI16198 [Go to this article.]

Figure 5
Noggin inhibits bone formation induced by proteasome inhibitors. Histologic sections of cultured murine neonatal calvarial bones treated with (a) media alone, (b) noggin (2 μg/ml), (c) epoxomicin (20 nM), (d) epoxomicin (20 nM) and noggin (2 μg/ml), (e) rhBMP-2 (100 ng/ml), (f) rhBMP-2 (100 ng/ml) and noggin (2 μg/ml), (g) aFGF (50 ng/ml), (h) aFGF (50 ng/ml) and noggin (2 μg/ml).