Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
J. Clin. Invest. I.R. Garrett, et al. 111:1771 doi:10.1172/JCI16198 [Go to this article.]

Figure 3
Proteasome inhibition correlates with bone formation. The stimulation of bone formation activity of these different proteasome inhibitors in calvarial bone organ cultures correlates strongly with the ability of these compounds to inhibit the activity of the proteasome. ED₅₀ is the effective dose required to either inhibit 50% of the proteasomal activity or stimulate 50% of the bone formation activity.