The α1A/C- and α1B-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse
J. Clin. Invest. Timothy D. O’Connell, et al. 111:1783 doi:10.1172/JCI16100 [
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Figure 4Heart and myocyte size in congenic 10- to 12-week-old male ABKO and WT mice. (
a) Whole-heart cross sections. Frozen sections of whole heart were stained with hematoxylin. ×2.5. The area of the ABKO section is 70% of that of the WT. (
b) Ventricular cross sections. Hearts were fixed in diastole, and coronal sections of the left ventricle were stained with 1% toluidine blue. Small clear areas are capillaries that mark myocyte borders. ×40. (
c) Isolated myocytes. ×20, phase contrast. Myocyte surface area was 3,259 ± 1,024 μm2 in WT mice (
n = 45) and 2,454 ± 812 μm2 in ABKO mice (
n = 41, 75% of WT,
P < 0.05).
