Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes
J. Clin. Invest. Raymond J. Steptoe, et al. 111:1357 doi:10.1172/JCI15995 [Go to this article.]

Figure 3
Transfer of NOD-PI HSCs or HPCs prevents development of diabetes. (a) Diabetes was prevented in recipients of NOD-PI HSCs (inverted triangles) compared with recipients of NOD HSCs (triangles) (P = 0.019) or untreated NOD mice (squares) (P = 0.029). NOD HSC recipients and untreated NOD mice did not differ significantly. (b) The incidence of diabetes was significantly reduced in recipients of NOD-PI HPCs (inverted triangles) compared with recipients of NOD HPCs (triangles) (P = 0.035) or untreated NOD mice (squares) (P = 0.021). NOD HPC recipients and untreated NOD mice did not differ significantly. Data are from one (a) or two (b) experiments in which BMT from NOD-PI and NOD mice was performed in parallel.