Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T
J. Clin. Invest. Maryam M. Javadpour, et al. 112:768 doi:10.1172/JCI15967 [
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Figure 1Sum of
31P NMR spectra from six 16-week-old NTG (left) and R92Q (right) hearts obtained during baseline perfusion with buffer containing either 11 mM glucose (top spectra) or 11 mM glucose with 0.5 mM pyruvate (bottom spectra). Resonance areas from left to right correspond to Pi, PCr, and γ-, α-, and β-phosphates of ATP. R29Q hearts had lower PCr and higher Pi resonance areas than did NTG hearts. PPM, parts per million.
