Differential subunit composition of the G protein–activated inward-rectifier potassium channel during cardiac development
J. Clin. Invest. Bernd K. Fleischmann, et al. 114:994 doi:10.1172/JCI15925 [Go to this article.]

Figure 5
Onset of current through recombinant I_K,ACh changes with the Kir3.1/Kir3.4 cRNA ratio. (A) Currents recorded from whole oocytes injected with the cRNAs indicated in response to voltage steps from 0 mV to potentials between _100 mV and 40 mV (increments of 20 mV); current and time scaling is 10 μA and 100 ms throughout. (B) Overlay of current responses obtained at _100 mV from oocytes injected with Kir3.1/Kir3.4 cRNA at a ratio of 10:1 (gray trace) or 1:10 (black trace). Note the difference in time course (τ_on of 16.6 ± 1.6 ms, n = 5; and 17.5 ± 3.9 ms, n = 4 for the 1:10 and 10:1 ratios, respectively). (C) I₀/I_max ratio as in Figure 4 measured in oocytes injected with Kir3.1 and Kir3.4 cRNA at the ratios indicated. Data are mean ± SD of 4_6 oocytes.