Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis
J. Clin. Invest. Wanhong Ding, et al. 111:1923 doi:10.1172/JCI15722 [
Go to this article.]
Figure 6A decreased DTH response was observed in vIL-10Tg mice. WT mice (groups A and C) and vIL-10Tg mice (groups B and D) were examined. Groups of vIL-10Tg and WT mice were injected subcutaneously with splenocytes from naive allogeneic CAF
1 mice (groups C and D) or were not immunized (groups A and B, negative control groups). Six days after immunization, all mice were challenged by subcutaneous injection of the left hind footpad with CAF
1 splenocytes and 24-hour footpad swelling was assessed as a measure of DTH response. Error bars represent ± SEM.
P = 0.007, C vs. D;
P = NS, A vs. B.
