Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis
J. Clin. Invest. Wanhong Ding, et al. 111:1923 doi:10.1172/JCI15722 [
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Figure 3Skin painting with FITC yields fewer hapten-bearing I-A
+ cells in draining lymph nodes. vIL-10Tg and WT mice were painted on the thorax and abdomen with FITC, and 18 hours later, inguinal and axillary lymph nodes were collected. DCs were isolated, and two-color analysis for I-A
q and FITC was performed. (
a) The difference in frequency of FITC-bearing cells from a single vIL-10Tg mouse and a single WT mouse. (
b) Comparison of mean frequency of hapten-bearing I-A
+ cells from groups of seven vIL-10Tg mice and seven WT mice. Error bars represent ± SEM.
P = 0.006, vIL-10Tg vs. WT.
