Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis
J. Clin. Invest. Wanhong Ding, et al. 111:1923 doi:10.1172/JCI15722 [Go to this article.]

Figure 2
I-A⁺ expression is reduced in the epidermis and dermis of vIL-10Tg, although a normal proportion of ATPase⁺ cells is present. (a) FACS analysis of I-A⁺ ECs from a single transgenic and a single WT mouse. (b) Comparison of mean percentage of I-A^q+ cells from groups of ten WT mice and ten vIL-10Tg mice. P = 0.0001. (c) Mean intensity of I-A^q expression of vIL-10Tg mice and WT mice. n = 5, both groups; P = 0.0124. (d) Frozen sections of truncal skin from vIL-10Tg and WT mice were prepared, and staining for I-A^q was carried out. Decreased numbers of I-A^q cells were seen in the dermis of vIL-10Tg mice. (e) Normal numbers of ATPase⁺ cells are present in vIL-10Tg mice. Epidermal sheets were prepared from the dorsum of vIL-10Tg mice and WT mice and stained for ATPase activity.