The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barré syndrome
J. Clin. Invest. Peggy C.R. Godschalk, et al. 114:1659 doi:10.1172/JCI15707 [
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Figure 5Anti-glycolipid antibodies in serum of mice before and after immunization with WT and mutant GB11
C. jejuni strains. (
A and
D) When sialic acid was present on the LOS core (WT and
orf11 mutant), anti-GD1a antibodies were induced in mice. (
B and
C) Anti-GD1a antibody responses were not detected in mice immunized with nonsialylated LOS (
cst-II and
orf10/orf11 mutants). (
F and
G) Nonsialylated LOS (
cst-II and
orf10/orf11 mutants) induced high asialo-GM1 antibody responses. (
E and
H) Asialo-GM1 antibody responses were absent or low after immunization with the
orf11 mutant and WT.
