The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barré syndrome
J. Clin. Invest. Peggy C.R. Godschalk, et al. 114:1659 doi:10.1172/JCI15707 [
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Figure 3Molecular mimicry between gangliosides and LOS outer cores of WT and mutant
C. jejuni strains. LOS outer core structures of GB2 and GB11 WT and mutant strains were determined by mass spectrometry analysis. The LOS outer core structure of the “genome” strain NCTC 11168 was described by St. Michael et al. (
35). Note that all strains express a mixture of different LOS structures. The
cst-II and
orf10/orf11 mutants of GB2 and GB11 expressed not ganglioside mimics but a mixture of 3 nonsialylated structures. No structural differences were observed between the WTs and the
orf11 mutants.
