The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barré syndrome
J. Clin. Invest. Peggy C.R. Godschalk, et al. 114:1659 doi:10.1172/JCI15707 [
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Figure 1Genetic organization of the 5 different classes of the
C. jejuni LOS biosynthesis locus. The distance between the scale marks is 1 kb. The direction of the arrows indicates the direction of transcription. Corresponding homologous genes have the same number with a letter for the LOS locus class added. For
orf1c and
orf13c the corresponding Cj gene numbers of the “genome” strain NCTC 11168 are given. The 5 LOS classes are based on DNA sequences of the following strains (GenBank accession number): class A: OH4384 (AF130984), OH4382 (AF167345), HS:4 (AF215659), HS:10 (AF400048), HS:19 (AF167344), HS:41 (AY044868); class B: HS:23 (AF401529), HS:36 (AF401528); class C: NCTC 11168 (AL139077), HS:1 (AY044156), HS:2 (AF400047); class D: LIO87 (AF400669); class E: 81116 (AF343914 and AJ131360). The proposed functions for the
orfs are described in Supplemental Table
1.