Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice
J. Clin. Invest. Scott P. Heximer, et al. 111:445 doi:10.1172/JCI15598 [Go to this article.]

Figure 4
Vasoconstrictor dose-response relationships and kinetics of blood pressure decline in wild-type and rgs2^–/– mice. (a) Dose-response relationships for blood pressure increase (change in MAP) upon challenge with increasing doses of the α-adrenergic vasoconstrictor phenylephrine in wild-type (n = 8; open squares) and rgs2^–/– mice (n = 7; filled squares) that had been pretreated with candesartan to decrease initial blood pressures to similar low basal levels. (b) Rates of blood pressure decrease [(MAP – MAP_final)/(MAP_initial – MAP_final)] ± SEM following challenge with a pressor dose of phenylephrine in wild-type (n = 6; open squares) and rgs2^–/– mice (n = 6; filled squares) pretreated with candesartan to decrease blood pressure to low basal levels.