Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
J. Clin. Invest. Xue-Bin Wu, et al. 112:924 doi:10.1172/JCI15543 [
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Figure 2Noggin expression assessed by β-gal staining in bone marrow cell cultures. Bone marrow cells from adult
noggin+/– mice were cultured for either 1 week (
a–
c) or 2 weeks (
d–
f) and stained for β-gal alone (blue,
a and
d) or β-gal with either ALP (red,
b and
e) or NSE (black in
c and
f) to identify cell types in the culture. Yellow arrowheads indicate cells that costain with β-gal and ALP or β-gal and NSE.