Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
J. Clin. Invest. Xue-Bin Wu, et al. 112:924 doi:10.1172/JCI15543 [
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Figure 1Noggin expression assessed by β-gal staining in adult bone tissues. Spine (
a,
b,
c, and
d) and calvaria (
e and
f) from adult 4-month-old
noggin+/– mice (
a,
c–
f) or
noggin+/+ mice (as a negative control) (
b) were stained for β-gal to investigate localization of cells expressing noggin.
d and
f represent polarized images corresponding to
c and
e, respectively. In
a, yellow and blue arrows indicate noggin-expressing hypertrophic chondrocytes and mesenchymal osteoblastic cells in the capsule around the vertebral disc, respectively. In
c, blue and yellow arrows indicate noggin-expressing osteoblasts/osteocytes in cortical bone and osteoblasts in trabecular bone, respectively. In
e, blue and yellow arrows indicate noggin-expressing osteoblasts of outer and inner calvaria, respectively.
