Increased plasma phenylacetic acid in patients with end-stage renal failure inhibits iNOS expression
J. Clin. Invest. J. Jankowski, et al. 112:256 doi:10.1172/JCI15524 [Go to this article.]

Figure 4
Nitrite formation in ECV304 cells. Nitrite accumulation was measured after 30 minutes with (stim) or without (unstim) stimulation of ECV304 with acetylcholine (1 μmol/l). ECV304 cells were stimulated with acetylcholine in the absence (stim) or presence of PAA (0.1 mmol/l, 0.5 mmol/l, 1.0 mmol/l, and 5.0 mmol/l) and L-NAME (10 μmol/l). Data are mean ± SEM (n = 6). *P < 0.05 compared with stimulation. L-NAME, N^G-nitro-L-arginine methyl ester.