Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
J. Clin. Invest. Florian P. Limbourg, et al. 110:1729 doi:10.1172/JCI15481 [Go to this article.]

Figure 2
Regulation of CBF by corticosteroids.(a) Representative pseudocolor image of CBF ([¹⁴C]iodoantipyrine autoradiography) from coronal brain sections 1 hour after MCAo in mice treated with dexamethasone (20 mg/kg) or vehicle. (b) Regional changes in absolute CBF ([¹⁴C]iodoantipyrine) in ipsilateral and contralateral brain areas of mice treated with dexamethasone (20 mg/kg administered intraperitoneally) or vehicle (n = 10 per group). (c) Changes in absolute CBF in eNOS^–/– mice were determined by the [¹⁴C]iodoamphetamine technique and expressed as percentages of contralateral CBF of vehicle-treated mice. *P < 0.05 vs. vehicle.