The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
J. Clin. Invest. David Vicent, et al. 111:1373 doi:10.1172/JCI15211 [Go to this article.]

Figure 4
Evaluation of time course of insulin action in control and VENIRKO mice by euglycemic-hyperinsulinemic clamp. Insulin was administered intravenously at time 0 as a bolus (40 mU/kg) and constant infusion (4 mU/kg/min) for the rest of the experiment. Euglycemia was maintained by glucose infusion. (a) Glucose infusion rates (mg/kg/min) in control (filled circle, n = 3) and VENIRKO (open circle, n = 3). (b) Blood glucose concentrations during the clamp.