Normal Th1 development following long-term therapeutic blockade of CD154-CD40 in experimental autoimmune encephalomyelitis
J. Clin. Invest. Laurence M. Howard, et al. 109:233 doi:10.1172/JCI14374 [Go to this article.]

Figure 4
Frequencies of PLP139-151–specific Th1, Th2, and Th0 cells are comparable 100 days after immunization in control- and anti-CD154–treated mice. Splenic and lymph node CD4⁺ T cells were taken 100 days after immunization, and ELISPOT was used to determine the frequencies of Th1 (IFN-γ–secreting) cells, Th2 (IL-5–secreting) cells, and Th0 (IL-2–secreting) cells from lymph node and splenic compartments of control- and anti-CD154–treated mice. Data, shown as mean ± SEM, were obtained from three pooled samples and represent two separate experiments.