β2 integrins are required for skin homing of primed T cells but not for priming naive T cells
J. Clin. Invest. Stephan Grabbe, et al. 109:183 doi:10.1172/JCI11703 [
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Figure 8Accumulation of
51Cr-labeled T cells and DCs at skin sites of ACD. Mice were sensitized and challenged with the hapten OXA. T cells and DCs were generated as described in Methods, labeled with
51Cr, and injected intravenously 24 hours after hapten challenge. Six hours later, ears and internal organs were harvested and
51Cr was counted. Data represent percentage of incorporated
51Cr in the ear in relation to the combined radioactivity uptake in lungs, liver, and spleen. *
P < 0.01 for WT versus
CD18–/– T cells;
P = not significant for all other groups.