β₂ integrins are required for skin homing of primed T cells but not for priming naive T cells
J. Clin. Invest. Stephan Grabbe, et al. 109:183 doi:10.1172/JCI11703 [Go to this article.]

Figure 7
ACD in CD18^–/– mice after subcutaneous injection of syngeneic LN cells. Left panel: CD18^–/– and WT mice were OXA-sensitized, and regional LNs were obtained. LN cells (2.5 × 10⁶) from sensitized or naive CD18^–/– mice were injected into ears of autologous OXA-challenged CD18^–/– mice, and 2.5 × 10⁶ LN cells from sensitized or naive WT mice were injected into ears of autologous OXA-challenged WT mice. Ear swelling responses were determined after 32 hours. P < 0.05 compared with transfer of naive LN cells of the same mouse strain. Right panel: The experiment was performed in a similar fashion as in the left panel, except that purified T cells from CD18^–/– mice were transferred in all cases. P < 0.05 compared with transfer of naive LN cells of the same mouse strain. No significant differences in ear swelling were present between ears injected with whole LN cells or purified T cells.