Peroxisome proliferator–activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor–deficient mice
J. Clin. Invest. Andrew C. Li, et al. 106:523 doi:10.1172/JCI10370 [Go to this article.]

Figure 3
Glucose and insulin responses to an oral glucose challenge in LDLR^–/– mice fed the normal chow (circles); high-fat, cholesterol-enriched diet and solvent (control; diamonds); rosiglitazone (squares); or GW7845 (triangles). Blood glucose and plasma insulin levels were determined at base line (after a 4-hour fast) and 15, 30, 60, and 90 minutes after oral administration of 0.75 mg glucose/g body weight. Samples were taken from eight animals per group. Data are expressed as the mean ± SEM. ^AP < 0.0001, ^BP < 0.002, ^CP < 0.015, and ^DP < 0.04, drug treatment group vs. control group.